Paradoxical mortality differential of HDL cholesterol

High-density lipoprotein (HDL) cholesterol has been known for ages to be cardio-protective due its defensive action against genesis of atherosclerosis. Increasing the serum HDL (HDL-C) as a prospective potential prevent coronary heart disease could not prove beneficial in human trials that put forward major concern about role and functional contribution HDL-C health. Many observational studies indicated extreme high value is often associated with cardiovascular mortality; therefore considered detrimental healthy survival. Furthermore, genetic revealed possible link between low serumHDL-C development common noncardiovascular diseases such infectious disease, autoimmune disorder, malignancy, type-2 diabetes, kidney, pulmonary diseases. This review endeavors update on various reasons mortality observed values reflected recent along probable pathogenesis these ailments.